During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives' utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life "the human centipede."

• Six Entertainment
• Dieter Laser
• Ashley C. Williams
• Ashlynn Yennie
• Akihiro Kitamura
• Andreas Leupold
• Peter Blankenstein
• Rosemary Annabella